Theseriescentersonthesurreala*enturesandanticsofthreeanthropomorphicfastfooditems:MasterShake,aselfish,pathologicallyingmilkshake;Frylock,anintelligent,well-meaningboxofFrenchfries;andMeatwad,ashapeshifting,*-mindedballofgroundmeat.Theylivetogetherasroommates,andrarelygetalongwiththeirhumanneighborCarlBrutananadilewski,abalding,middle-aged,*-crazedsportsfanatic.Themainprotagonistsalsointeractwithvariousvillainsorotherindividualsineachepisode;theseinteractionsareoftenrestrictedtooneepisode,a*inorcharactersrarelyreappearinfollowingepisodes.Someepisodesfeaturethemainprotagonistsinteractingwithcelebrities(suchas*filmactressTeraPatrick)andoccasionallywithhistoricalfiguresandprofessionalathletes(suchasBartOatesorJohnKruk).TheMooninitesaretwoaliensfromtheMoonwhofrequentlyappear,servingasprimaryantagonistsandwreakingh*octhroughaseriesofillegalordestructiveactions.TheMooninitesappearmorethanmostcharactersoutsideofthemaincast.Otherrecurringcharactersh*emadeseveralappearances,includingOglethorpeandEmory,MCPeePants,CyberneticGhostofChristmasPastfromtheFuture,andDr.Wongburger.Episodesoftenendwiththenon-canondeathsorinjuriesofmajorcharacters,ordestructiontotheirproperty(bothCarl'sandtheprotagonists'homesh*ebeendamagedordestroyedinmultipleepisodes),onlytoberestoredwithnoexplanationormentioninthefollowingepisode.